Micky van de Ven Double Ends Everton's Run at New Stadium
Micky van de Ven became the first defender to score twice in a Premier League game for Tottenham since the Belgian defender in spring 2013.
Match summary
Micky Van de Ven nods home twice in opening period
The home side's Jake O'Brien has goal ruled after video check
Pape Matar Sarr nets third in 89th minute
The defeat is the Merseyside club's first at their new ground
The Tottenham defender scored twice as Spurs prolonged their unbeaten run on the road in the top division and delivered the Toffees their first defeat at their new home.
The Toffees were unbeaten in their last five matches at their new ground at the dockside location, having departed Goodison Park behind after 133 years at the end of the previous campaign.
But Tottenham's leader the Dutchman struck twice from set-pieces in the opening 45 minutes to put their strong form at jeopardy, and they were unable to turn it around before the midfielder - set up by ex-Everton forward the Brazilian - nodded in a third to put the game to bed.
Jake O'Brien thought he had levelled the scores five minutes after Van de Ven's opener, glancing a powerful header past the Spurs keeper from an Everton corner.
The Portuguese striker, in the meantime, failed to convert a handful of chances, while Vicario made a succession of fine stops to ensure Tottenham went five away games without defeat in the Premier League.
But the VAR stepped in, instructing Craig Pawson to check the score on the pitchside monitor and the referee decided that Jack Grealish and Iliman Ndiaye were in offside positions and had impeded with the Spurs keeper.
This victory elevates the manager's team up to third in the division, five points off local foes and table-toppers the Gunners.
The Merseyside club stay in 14th position and sit six points ahead of the drop zone.
Tottenham analysis: Van de Ven fulfils role at both ends of the field
After a drab weekday performance in the Champions League against Monaco, where they managed a only two shots on target, the manager chose Randal Kolo Muani up front instead of former Toffees player the Brazilian.
The summer signing was failed to influence the game before being replaced for Richarlison after an hour on the field, but it emerged he wasn't needed in the end.
Centre-back the Dutchman converted into an offensive threat to be feared.
Tottenham's first goal came from a cleverly executed set-piece play, with Rodrigo Bentancur heading the ball back across the six-yard box for an unmarked the defender to head home.
And the captain - filling in as captain in Cristian Romero's absence - added his second in added time as he outjumped the England keeper to nod in.
Van de Ven was just as outstanding in defence, combining effectively with Kevin Danso as the pair handled superbly with the 34 crosses thrown their way by Everton.
Toffees breakdown: Toffees lacking finishing touch
Everton's recent stadium had been a happy hunting ground, but it appears the novelty may have worn off somewhat and fans headed to the exits after Sarr's third for Tottenham.
The end in Everton's winning streak at home won't be a massive worry for David Moyes, but their striker situation are.
Beto and the other striker - the Toffees' pair of established strikers - had scored only a single goal combined before Sunday's match.
And they were unable to contribute to that poor record on a damp and dreary evening on in Liverpool.
Beto's performance was epitomized when he opted to overhead kick a clear chance from close range, despite having room and time to reposition for a more conventional attempt that would have challenged Vicario.
Barry, too, failed to make an impact after replacing the starter in the 65th minute.
It was not for a shortage of opportunity. Most of Everton's attacks came through the winger and Ndiaye, who tirelessly whipped threatening crosses into the Spurs penalty area.
What next for these two sides?
Everton: Moyes' men travel to Sunderland in the Premier League on Monday, 3 November at 8 PM.
Spurs: Spurs go to St James' Park on Wednesday, 29 October for their next round Carabao Cup match against the Magpies.